Vial Imipenem-Cilastatin 500mg/500 mg ( contains strile powder for injection)

Generic Name of ProductBrand NameDosage Form StrengthPharmacologic GroupTherapeutic GroupUnit Per Pack
Imipenem/cilastatinSupranemVial500mgCarbapenemAntibacterial Agent12

Indications And Usage

for intravenous use is indicated for the treatment of lower respiratory tract infections caused by susceptible strains of Staphylococcus aureus (penicillinase-producing isolates), Acinetobacter species, Enterobacter species, Escherichia coli, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella species, Serratia marcescens.


If the infection is suspected or proven to be due to a susceptible bacterial species 500 mg every 6 hours or
1,000 mg every 8 hour. If the infection is suspected or proven to be due to bacterial species with intermediate susceptibility. 1,000 mg every 6 hours.


Imipenem and Cilastatin for Injection (I.V.) is contraindicated in patients who have shown hypersensitivity to any component of this product.


Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. These reactions are more likely to occur in individuals with a history of sensitivity to multiple allergens.

Adverse Reactions

Hypersensitivity Reactions/Seizure Potential/Seizure Potential Due to Interaction with Valproic Acid/Diarrhea

Pregnancy and lactation

Category C

Renal and liver Impairment

Patients with creatinine clearance less than 90 mL/min require dosage reduction of Imipenem and Cilastatin for Injection.

Laboratory Tests
(SGOT),(SGPT), increased urine protein, decreased neutrophils.