Indications And Usage

For relief of the signs and symptoms of osteoarthritis.

For relief of the signs and symptoms of rheumatoid arthritis.

Administration

Administer by deep intramuscular injection into the upper, outer quadrant of the buttock.

May be associated with gastro-protective agents.

Adults and adolescents (> 15 years of age):

Recommended maximum daily dose: 20 mg.

Elderly, renal and hepatic impairment: to be taken with caution.

Treatment duration: 2 or 3 days. Lopirox tablets should be used for treatment continuation.

IV incompatibilities: Incompatible with all drugs

Contraindications

Children under 15 years’ old, Coagulation disorder if used intramuscularly, Gastrointestinal hemorrhage, History of aspirin-induced asthma attack, History of Crohn's disease, History of cutaneous hypersensitivity, History of gastrointestinal cancer, History of gastrointestinal hemorrhage, History of gastrointestinal perforation, History of nonsteroidal anti-inflammatory drugs [NSAIDs]-induced asthma attack, History of peptic ulcer, History of ulcerative colitis [UC], Hypersensitivity to nonsteroidal anti-inflammatory drugs [NSAIDs], Hypersensitivity to one of the components, Hypersensitivity to oxicam derivatives, Hypersensitivity to salicylates, Inflammatory gastrointestinal pathology, Patients on anticoagulants, Progressive peptic ulcer, Recent history of diverticulitis, Severe heart failure, Severe hepatic failure, Severe renal failure: creatinine clearance < 30 ml/min, Last 4 months of pregnancy

Precautions

Asthma, Chronic renal failure, Congestive heart failure, Coronary insufficiency, Decompensated liver cirrhosis, Elderly patients, Heart failure, History of cerebrovascular accident [CVA], History of heart failure, History of hypertension, Hypovolemia, Lupus nephritis, Nephrotic syndrome, Patients over 70 years old, Peripheral arteriopathy, Prolonged treatment, Slow metaboliser, Uncontrolled hypertension, First 5 months of pregnancy, Lactation

Adverse Reactions

Cardiovascular Thrombotic Events, GI Bleeding, Ulceration and Perforation , Hepatotoxicity, Hypertension, Heart Failure and Edema, Renal Toxicity and Hyperkalemia, Anaphylactic Reactions, Serious Skin Reactions, Hematologic Toxicity

Pregnancy and lactation

Pregnancy (months):

1,2,3,4,5: Precaution

6,7,8,9: Absolute contraindication

Renal and liver Impairment

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Laboratory Tests