Indications And Usage

Herpes simplex infections.

Administration

5 mg/kg infused at a constant rate over 1 hour, every 8 hours for 7 days.

Contraindications

Acyclovir Sodium Injection is contraindicated for patients who develop hypersensitivity to acyclovir or valacyclovir.

Precautions

Approximately 1% of patients receiving intravenous acyclovir have manifested encephalopathic changes characterized by either lethargy, obtundation, tremors, confusion, hallucinations, agitation, seizures, or coma.  Acyclovir should be used with caution in those patients who have underlying neurologic abnormalities and those with serious renal, hepatic, or electrolyte abnormalities, or significant hypoxia.

Adverse Reactions

The most frequent adverse reactions reported during administration of acyclovir were inflammation or phlebitis at the injection site

Pregnancy and lactation

Category B.

Renal and liver Impairment

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Laboratory Tests