syrup Diphenhydramine Compound

Generic Name of ProductBrand NameDosage Form StrengthPharmacologic GroupTherapeutic GroupUnit Per Pack
Diphenhydramine Compound*-syrup12.5 mg+125 mg/ 5ml (60 ml)histamine H1 receptorAntihistamines1

Indications And Usage

It is used to ease allergy signs.

It is used to relieve coughing.

It is used to thin mucus so it can be taken from the body by coughing.

It is used to help motion sickness.


Oral dose of Diphenhydramine Compound for adults is 30-50 mg 1-3 times / day. The treatment course is 10-15 days. As soporific - 50 mg at bedtime.


Hypersensitivity to diphenhydramine, other structurally related antihistamines, or any component of the formulation; neonates or premature infants; breast-feeding

Parenteral: Use as a local anesthetic.

do not use in children <6 years, to make a child sleep, or with any other diphenhydramine-containing products

Severe hepatic or renal impairment


This medication contains ammonium chloride. Do not take ammonium chloride if you are allergic to ammonium chloride or any ingredients contained in this drug.

Asthma: Use with caution in patients with a history of asthma.

• Cardiovascular disease: Use with caution in patients with cardiovascular disease (including hypertension and ischemic heart disease).

• Increased intraocular pressure/glaucoma: Use with caution in patients with increased intraocular pressure or angle-closure glaucoma.

• Prostatic hyperplasia/urinary obstruction: Use with caution in patients with prostatic hyperplasia, bladder neck obstruction, and/or GU obstruction.

• Pyloroduodenal obstruction: Use with caution in patients with pyloroduodenal obstruction (including stenotic peptic ulcer).

• Thyroid dysfunction: Use with caution in patients with thyroid dysfunction.

Adverse Reactions

Metabolic acidosis, Rash, EEG abnormalities, Seizures, Mental confusion, Irritability, Drowsiness, Injection site reactions, Ammonia toxicity symptoms (sweating, altered breathing, slow heart rate, irregular heartbeats, and coma), Calcium-deficient leading to tetany, Low blood potassium (hypokalemia), High chloride levels in the blood (hyperchloremia), Abdominal pain, Nausea/vomiting, Hyperventilation, Encephalopathy.

Pregnancy and lactation

B group in pregnancy.

Small, occasional doses of diphenhydramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply

Pregnancy: Use ammonium chloride with caution during pregnancy if benefits outweigh risks. Animal studies show risk and human studies are not available or neither animal nor human studies were done.

There is no information available about use of ammonium chloride while breastfeeding. Consult your doctor.
Renal and liver Impairment

Do not use in Severe hepatic or renal impairment

Laboratory Tests