Indications And Usage

for intravenous use is indicated for the treatment of lower respiratory tract infections caused by susceptible strains of Staphylococcus aureus (penicillinase-producing isolates), Acinetobacter species, Enterobacter species, Escherichia coli, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella species, Serratia marcescens.

Administration

If the infection is suspected or proven to be due to a susceptible bacterial species 500 mg every 6 hours or
1,000 mg every 8 hour. If the infection is suspected or proven to be due to bacterial species with intermediate susceptibility. 1,000 mg every 6 hours.

Contraindications

Imipenem and Cilastatin for Injection (I.V.) is contraindicated in patients who have shown hypersensitivity to any component of this product.

Precautions

Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. These reactions are more likely to occur in individuals with a history of sensitivity to multiple allergens.

Adverse Reactions

Hypersensitivity Reactions/Seizure Potential/Seizure Potential Due to Interaction with Valproic Acid/Diarrhea

Pregnancy and lactation

Category C

Renal and liver Impairment

Patients with creatinine clearance less than 90 mL/min require dosage reduction of Imipenem and Cilastatin for Injection.

Laboratory Tests